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Your last-minute guide to Proposition 38: Research funding for immunology, immunotherapy

Dr. William Zeigler, Assistant Professor in Residence in the Department of Neurology at UCLA.
Dr. William Zeigler, an assistant professor at UCLA, joins other faculty and researchers in Westwood at a “Science Fair for Suspended Research” in the fall of 2025 after more than $500 million in federal research grants was suspended.
(Genaro Molina / Los Angeles Times)
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The Trump administration has frozen, terminated or delayed billions in congressionally approved research grants since last year. Proposition 38 aims to backfill some of that loss by creating a stable source of money to fund immunology and immunotherapy research.

The basics

Proposition 38 would authorize the state to issue $8.4 billion in bonds to fund immunology and immunotherapy research to uncover treatments that help the immune system fight diseases such as cancer and Alzheimer’s disease more efficiently.

The impact

The measure would require at least $4.2 billion of the funds to be used for immunology research on cancer, heart disease and Alzheimer’s. It also would authorize the state to enter a partnership with an immunology and immunotherapy research institute selected by the California Department of Public Health and allocate half of the bond revenue to it. The remaining funds would be used for competitive grants that focus solely on immunology and immunotherapy research.

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Californians would take on an increased cost of $500 million to $600 million annually to repay the bond for about 20 years, according to the Legislative Analyst’s Office.

The Yes on 38 campaign says the proposition pays for itself: 10% of all proceeds from the licensing of immunotherapies must be returned to the state to offset the total cost of the bond measure, including interest.

However, it’s difficult to predict whether any research projects will lead to marketable treatments.

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Prop 38 aims to fund immunotherapy research to prevent and cure diseases through bonds. An opponent says it is a debt-financed model that prioritizes a few diseases.

Dig deeper

Proposition 38 is backed by organizations including the Michael J. Fox Foundation for Parkinson’s Research and the ALS Assn., as well as a majority of local chapters of Democratic organizations across the state. Supporters say the proposed funding could give those afflicted with chronic illness hope and potentially more options for treatment.

Its opponents have said the proposed criteria for awarding the grant funding would appear to create an extremely small pool of qualified recipients. Only the California Institute for Immunology and Immunotherapy, co-founded by billionaire Gary K. Michelson, would qualify under the proposed criteria, according to No on 38, the campaign against the proposition.

Robin Swanson, spokesperson for the Yes on 38 campaign, said “lots of institutions would qualify for funds under this measure.”

But she said at a virtual news conference in mid-September that it was “very likely” that the California Institute for Immunology and Immunotherapy “will qualify for half of the funds under the current criteria.”

Ultimately, Swanson said, the decision lies with the California Department of Public Health.

More reading

Your guide to Proposition 38: Immunology and immunotherapy research funding (L.A. Times)

An analysis of Prop. 38 (California Legislative Analyst’s Office)

This CA proposition will send $4 billion to a single nonprofit. Who’s behind it? (Cal Matters)

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This institute could get $4 billion from a ballot measure. With just three workers, is it ready? (Cal Matters)

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